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During the experimental session, the house cage (with food items and water taken off) was placed on major of the telemetry receiver. 3 telemetry receivers ended up situated in three independent but equivalent seem-attenuation chambers. Coronary heart price and mean arterial blood pressure have been sampled just about every minute and were monitored
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The locomotor stimulation induced by MC and 3-FMC is mediated by activation of dopaminergic neurotransmission, as selective D1-dopamine receptor antagonist, SCH 23390, abolished the consequences of each drugs. According to pharmacological details attained by prior in vitro studies, MC and 3-FMC developed strong raises of extracellular dopamine and